Peeling skin syndrome

Peeling skin syndrome is an autosomal recessive disorder marked by lifelong peeling of the stratum corneum, the outer layer of the skin. It may be accompanied by itching, short stature and hair that is easily pulled out. In the acral form the peeling is most noticeable on the hands and feet, though it sometimes also affects the arms and legs. The peeling is usually apparent from birth, although it can begin in childhood or later in life, and it is brought on by sun, humidity, moisture and friction. The condition has several other names, including acral peeling skin syndrome, continual peeling skin syndrome, familial continual skin peeling, idiopathic deciduous skin and keratolysis exfoliativa congenita, and the acral form can be associated with TGM5. This entry is a reference record and not medical advice.