Pelger-Huët anomaly

Pelger-Huët anomaly is a blood laminopathy linked to the lamin B receptor. Several types of white blood cell, including neutrophils and eosinophils, have nuclei of unusual shape, bilobed, peanut-shaped or dumbbell-shaped rather than the normal three lobes, and with a coarse, lumpy structure. It is a genetic disorder with an autosomal dominant inheritance pattern. People with one copy of the variant are clinically normal, although their neutrophils can be mistaken for immature cells, which may lead to mistreatment in a clinical setting. People with two copies tend to have neutrophils with rounded nuclei and some functional problems.