X-linked intellectual disability

X-linked intellectual disability is a group of medical disorders that follow X-linked recessive inheritance and result in intellectual disability. As with most X-linked conditions, males are more heavily affected than females, and a female carrying one affected X chromosome alongside a normal one tends to have milder symptoms. Unlike many other kinds of intellectual disability, the genetics are relatively well understood: around 200 genes are thought to be involved, of which about 100 have been identified, and many lie on the short arm of the X chromosome. The group accounts for roughly sixteen percent of intellectual disability in males. Named syndromes that include it as a feature are Coffin-Lowry syndrome, DDX3X syndrome, MASA syndrome and MECP2 duplication syndrome. The atlas records it as a description, not as medical advice.