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Drugs and Medicinal Substances

Charlotte's Web (cannabis)

Nervous System Agents

Charlotte's Web is a high cannabidiol, low tetrahydrocannabinol cannabis product developed by the Stanley Brothers in Colorado by crossbreeding marijuana with industrial hemp. The strain contains less than 0.3 percent THC and was originally nicknamed Hippie's Disappointment because it produced no psychoactive high. It is named after Charlotte Figi, a child with Dravet syndrome whose seizures improved dramatically after using the extract, and it gained wide attention after a 2013 CNN documentary by Dr. Sanjay Gupta. The related pharmaceutical Epidiolex, a CBD based medicine, was approved by the FDA in 2018 for certain forms of epilepsy, though rigorous clinical evidence for Charlotte's Web itself remains limited.

Facts
Drug Class
High-cannabidiol, low-tetrahydrocannabinol hemp product 1
Approved Use
Marketed as a dietary supplement and cosmetic rather than an approved drug itself; the related medicine Epidiolex, which uses CBD as its therapeutic ingredient, was approved by the FDA in 2018 for two types of epilepsy 1
Significant Risk
Regulators and reviewers found insufficient evidence to draw firm conclusions about its safety or efficacy 1
Classification
Approval Status
Not Approved 1
ATC ClassSourced to the subject's own account
N: Nervous System 2
Route of Administration
Oral 1
Connections

Long-Form Articles

Sources
1. Charlotte's Web (cannabis) (Wikipedia)
  • Lead section, opening sentence
    a brand of high-cannabidiol (CBD), low-tetrahydrocannabinol (THC) products derived from industrial hemp
  • Lead section, Epidiolex sentence
    In 2018, Epidiolex (cannabidiol as the therapeutic ingredient) oral solution was approved by the FDA for two types of epilepsy
  • Lead section, safety evidence sentence
    there was not enough evidence to draw conclusions with certainty about their safety or efficacy
  • Regulatory approval status
  • Route of administration
View the Source
2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code N
Quote, First-level anatomical group codes, Code N
Nervous system
View the Source
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