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Drugs and Medicinal Substances

Cimetidine

Alimentary Tract and Metabolism Agents

Cimetidine is a small-molecule medicine with the molecular formula C10H16N6S and a molecular weight of about 252.35, recorded in the ChEMBL database as an approved drug whose first approval year is 1977. Its nonproprietary name carries the stem -tidine, which ChEMBL defines as the H2-receptor antagonists of the cimetidine type. The WHO Anatomical Therapeutic Chemical index files it as A02BA01 among the H2-receptor antagonists, inside the group for drugs for peptic ulcer and gastro-oesophageal reflux disease, and assigns it a defined daily dose of 0.8 g for oral use. ChEMBL lists its approved indications as gastroesophageal reflux, peptic ulcer, duodenal ulcer and heartburn. This entry records classification and approval facts only and is not medical advice.

Facts
Classification
Approval Status
Approved 1
ATC Class
A: Alimentary Tract and Metabolism 2
Route of Administration
Oral 1
WHO Essential Medicine
Core List 3
First Approved / Isolated Year
1977 1
Connections

Treats

Source ChEMBL, EMBL-EBI: Cimetidine approved indications (ChEMBL)
Source ChEMBL, EMBL-EBI: Cimetidine approved indications (ChEMBL)
Sources
1. Cimetidine (ChEMBL molecule record)
  • ChEMBL molecule record, first_approval
    "first_approval": 1977
  • ChEMBL molecule record, max_phase 4
    "max_phase": "4.0"
  • ChEMBL molecule record, oral flag
    "oral": true
View the Source
2. ChEMBL, EMBL-EBI: ChEMBL molecule record CHEMBL30 (Cimetidine)
ChEMBL, EMBL-EBIatc_classifications of the molecule record; ATC class derived from cited code A02BA51 (main group A)
Quote, atc_classifications of the molecule record; ATC class derived from cited code A02BA51 (main group A)
"atc_classifications": [ "A02BA51", "A02BA01" ], "molecule_chembl_id": "CHEMBL30", "pref_name": "CIMETIDINE"
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3. World Health Organization: The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list
World Health OrganizationSection 17.1, page 51, ranitidine entry and its A02BA alternative
Quote, Section 17.1, page 51, ranitidine entry and its A02BA alternative
4th level ATC chemical subgroup (A02BA H2-receptor antagonists) excluding combinations
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ChEMBL, EMBL-EBI: Cimetidine approved indications (ChEMBL)
ChEMBL, EMBL-EBI
  • Treats: Gastroesophageal Reflux Disease, drug_indication record, maximum phase 4, MeSH heading Gastroesophageal Reflux
    "max_phase_for_ind": "4.0", "mesh_heading": "Gastroesophageal Reflux", "molecule_chembl_id": "CHEMBL30"
  • Treats: Peptic Ulcer Disease, drug_indication record, maximum phase 4, MeSH heading Peptic Ulcer
    "max_phase_for_ind": "4.0", "mesh_heading": "Peptic Ulcer", "molecule_chembl_id": "CHEMBL30"
View the Source
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