Fluconazole is an antifungal medication used for a number of fungal infections, including candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis and tinea versicolor, given orally or intravenously. It is a first-generation triazole that inhibits the fungal cytochrome P450 enzyme 14-alpha-demethylase, blocking the conversion of lanosterol to ergosterol, a component the fungal cell membrane depends on. Fluconazole was developed by Pfizer, patented in 1981 and came into commercial use in 1988; it is now available as a generic medication and appears on the World Health Organization's List of Essential Medicines.
Facts
Classification
Approval Status ATC ClassSourced to the subject's own accountJ: Antiinfectives for Systemic Use 2 Route of Administration Route of Administration Route of Administration WHO Essential MedicineSourced to the subject's own account Drug ClassTriazole antifungal (azole class) 1 Mechanism of ActionBelieved to work by affecting the fungal cellular membrane 1 Approved UseCandidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis and tinea versicolor 1 First Approved / Isolated Year Significant RiskLiver problems, QT prolongation and seizures 1 Sources
1. Fluconazole (Wikipedia)
Section: Medical uses, starting at character 0
Fluconazole is a first-generation triazole antifungal medication.
Section: Side effects and mechanism, starting at character 300
It is believed to work by affecting the fungal cellular membrane.
Lead section, paragraph 1, starting at character 130
These include candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor.
Section: History and culture, starting at character 0
Fluconazole was patented in 1981 and came into commercial use in 1988.
Section: Side effects and mechanism, starting at character 83
Serious side effects may include liver problems, QT prolongation, and seizures.
- Regulatory approval status
View the Source2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code JQuote, First-level anatomical group codes, Code J
Antiinfectives for systemic use
3. Fluconazole (Wikipedia)
WikipediaInfobox drug, routes_of_administrationQuote, Infobox drug, routes_of_administration
By mouth, intravenous, topical
4. WHO Model List of Essential Medicines (Wikipedia)
WikipediaWHO Model List of Essential Medicines, Antifungal medicines sectionQuote, WHO Model List of Essential Medicines, Antifungal medicines section
Fluconazole
Reader Challenges (0)
No disputes yet. Spotted an error or a better source? Open the first one.
Sign in to dispute this or suggest a correction.