Fosinopril

Fosinopril is an angiotensin converting enzyme inhibitor used to treat hypertension and some kinds of chronic heart failure. It is the only phosphonate-containing ACE inhibitor on the market, and Bristol-Myers Squibb sold it under the trade name Monopril. It acts as a cascading pro-drug, meaning the body converts it in steps into its active form. What sets it apart from the other members of the ACE inhibitor class is that it was developed specifically for patients with renal impairment: about half of the drug is cleared through the liver and bile, which compensates for reduced kidney clearance, while the other half is excreted in urine, so it does not need dose adjustment. It was patented in 1980 and approved for medical use in 1991. This entry records what is held about the drug and is not medical advice.