Interferon gamma-1b is a protein medicine, a recombinant form of the signalling molecule interferon gamma, given by injection. ChEMBL records its first approval in 1999, and the WHO Anatomical Therapeutic Chemical Index classifies it as L03AB03, among the interferons of the immunostimulant group. The approved indication recorded for it is osteopetrosis, a rare inherited bone disorder in which bone is abnormally dense. It is not on the World Health Organization Model List of Essential Medicines, 24th list, from 2025. Actimmune is the brand name under which it is sold, and the queued entry for it was filed under that name.
Facts
Classification
Approval Status ATC ClassL: Antineoplastic and Immunomodulating Agents 2 Route of Administration First Approved / Isolated Year Connections
Treats
Source ChEMBL, EMBL-EBI: Interferon gamma-1b approved indications (ChEMBL)
Sources
1. Interferon gamma-1b (ChEMBL record)
ChEMBL molecule record, first_approval
"first_approval": 1999
ChEMBL molecule record, maximum phase and withdrawn flag
"max_phase": "4.0"
View the Source2. ChEMBL, EMBL-EBI: ChEMBL molecule record CHEMBL1201564 (Interferon gamma-1b)
ChEMBL, EMBL-EBIatc_classifications of the molecule record; ATC class derived from cited code L03AB03 (main group L)Quote, atc_classifications of the molecule record; ATC class derived from cited code L03AB03 (main group L)
"atc_classifications": [ "L03AB03" ], "molecule_chembl_id": "CHEMBL1201564", "pref_name": "INTERFERON GAMMA-1B"
3. National Library of Medicine, DailyMed: DailyMed label: ACTIMMUNE (interferon gamma-1b) injection
National Library of Medicine, DailyMedActimmune label, Dosage and AdministrationQuote, Actimmune label, Dosage and Administration
For subcutaneous use only
ChEMBL, EMBL-EBI: Interferon gamma-1b approved indications (ChEMBL)
ChEMBL, EMBL-EBITreats: Osteopetrosis, drug_indication record, maximum phase 4, MeSH heading OsteopetrosisQuote, Treats: Osteopetrosis, drug_indication record, maximum phase 4, MeSH heading Osteopetrosis
"max_phase_for_ind": "4.0", "mesh_heading": "Osteopetrosis", "molecule_chembl_id": "CHEMBL1201564"
Reader Challenges (0)
No disputes yet. Spotted an error or a better source? Open the first one.
Sign in to dispute this or suggest a correction.