Phenoxymethylpenicillin, also known as penicillin V, PcV and penicillin VK, is an antibiotic taken by mouth. It is used to treat strep throat, otitis media and cellulitis, to prevent rheumatic fever, and to prevent infections after the spleen has been removed. It belongs to the penicillin and beta lactam families of medications and usually works by killing bacteria. Side effects include diarrhea, nausea and allergic reactions up to anaphylaxis, and it is not recommended for anyone with a history of penicillin allergy, though it is relatively safe in pregnancy. It was first made in 1948 by Eli Lilly. It is on the World Health Organization List of Essential Medicines and is available as a generic. In 2023 it was the 248th most commonly prescribed medication in the United States, with more than one million prescriptions. This entry records what is held about the drug and is not medical advice.
Facts
Classification
Approval Status ATC ClassJ: Antiinfectives for Systemic Use 2 Route of Administration WHO Essential Medicine First Approved / Isolated Year Sources
1. EMBL-EBI ChEMBL: ChEMBL molecule record CHEMBL615 (penicillin V)
EMBL-EBI ChEMBLfirst_approvalQuote, first_approval
"first_approval": 1958
View the Source 2. WHO Collaborating Centre for Drug Statistics Methodology, ATC/DDD Index: the WHO ATC/DDD Index entries named Phenoxymethylpenicillin
WHO Collaborating Centre for Drug Statistics Methodology, ATC/DDD IndexATC/DDD Index entry; ATC class derived from cited code J01CE02 (main group J)Quote, ATC/DDD Index entry; ATC class derived from cited code J01CE02 (main group J)
J01CE02 phenoxymethylpenicillin
View the Source 3. Phenoxymethylpenicillin (Wikipedia)
Lead section of the English Wikipedia article
Phenoxymethylpenicillin was first made in 1948 by Eli Lilly.
Lead section of the English Wikipedia article [route-of-administration]
It is given by mouth.
View the Source4. World Health Organization: The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list
World Health OrganizationPDF page 19; section 6.2.1; the entry phenoxymethylpenicillin is in the Core List of the WHO Model List of Essential Medicines, 24th list (2025)Quote, PDF page 19; section 6.2.1; the entry phenoxymethylpenicillin is in the Core List of the WHO Model List of Essential Medicines, 24th list (2025)
phenoxymethylpenicillin FIRST CHOICE
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