Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases.
Facts
Drug ClassGlucocorticoid (corticosteroid) 1 Mechanism of ActionA prodrug converted by the liver to prednisolone, which binds glucocorticoid receptors and alters gene expression, inhibiting leukocyte function and reducing their numbers in the bloodstream. 1 Approved UseSuppresses the immune system and decreases inflammation in conditions such as asthma, COPD and rheumatologic disease. 1 First Approved / Isolated Year Significant RiskCataracts, bone loss, easy bruising, muscle weakness and thrush; also weight gain, swelling, high blood sugar, increased infection risk and psychosis. 1 Prescription Status Mechanism of Action Classification
Approval Status ATC ClassSourced to the subject's own accountH: Systemic Hormonal Preparations, Excluding Sex Hormones and Insulins 2 Route of Administration WHO Essential Medicine Connections
Treats
Bell's Palsy, Conditions Oral corticosteroids (prednisone) are the standard early treatment for Bell's palsy.
Source Prednisone (Wikipedia)
Source Prednisone (Wikipedia)
Sarcoidosis, Conditions Corticosteroids (prednisone) are the standard first-line treatment for symptomatic sarcoidosis.
Source Prednisone (Wikipedia)
Sources
1. Prednisone (Wikipedia)
Wikimedia FoundationLead section
used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases
Infobox, drug class
Glucocorticoid
Mechanism of action section
Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active.
History section
Prednisone was patented in 1954 and approved for medical use in the United States in 1955.
Adverse effects section
Common side effects may include cataracts, bone loss, easy bruising, muscle weakness, and thrush.
https://en.wikipedia.org/wiki/Prednisone, lead section
insufficiency along with other corticosteroids. It is taken by mouth.
- Regulatory approval status
- WHO Model List of Essential Medicines, core list
View the Source 2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code HQuote, First-level anatomical group codes, Code H
Systemic hormonal preparations, excluding sex hormones and insulins
3. Wikipedia
Wikipedia contributors, Wikimedia Foundation- Route of Administration: Oral
4. U.S. Food and Drug Administration (openFDA): openFDA drug labels of Prednisone by product type
U.S. Food and Drug Administration (openFDA)count by product typeQuote, count by product type
"term": "HUMAN PRESCRIPTION DRUG", "count": 238
5. ChEMBL: ChEMBL mechanism of action for Prednisone (CHEMBL635)
ChEMBLmechanism_of_actionQuote, mechanism_of_action
Glucocorticoid receptor agonist
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