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Drugs and Medicinal Substances

Tranexamic acid

Blood and Blood Forming Organ Agents

Tranexamic acid is a synthetic medication used to treat or prevent excessive blood loss. It acts as an antifibrinolytic, reversibly binding four to five lysine receptor sites on plasminogen to prevent the breakdown of fibrin, and it is used for conditions ranging from major trauma and postpartum hemorrhage to heavy menstrual bleeding and dental procedures. It was developed by the Japanese researchers Shosuke and Utako Okamoto in 1962 and is on the World Health Organization's List of Essential Medicines. Side effects are rare but can include seizures, changes in vision, blood clots, and allergic reactions, and the drug is available generically as oral tablets, intravenous injections, and topical formulations.

Facts
Drug Class
Antifibrinolytic; synthetic lysine analog 1
Mechanism of Action
Reversibly binds lysine receptor sites on plasminogen, preventing fibrin degradation 1
Approved Use
Treats or prevents excessive blood loss from trauma, postpartum bleeding, surgery and heavy menstruation 1
Significant Risk
Rare seizures, color vision changes, blood clots and allergic reactions 1
Classification
Approval Status
Approved 1
ATC ClassSourced to the subject's own account
B: Blood and Blood Forming Organs 2
Route of Administration
Intravenous 3
WHO Essential MedicineSourced to the subject's own account
Core List 4
Partially Attested
First Approved / Isolated Year
1962 1
Source gives year first synthesized, not first approval
Sources
1. Tranexamic acid (Wikipedia)
  • Lead section, paragraph 2, first sentence
    Tranexamic acid is a synthetic analog of the amino acid lysine
  • Lead section, paragraph 2, second sentence
    It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen
  • Lead section, paragraph 1
    used to treat or prevent excessive blood loss from major trauma, postpartum bleeding
  • Lead section, paragraph 5
    first made in 1962 by Japanese researchers
  • Lead section, paragraph 4
    Side effects are rare; they include changes in color vision, seizures, blood clots, and allergic reactions
  • https://en.wikipedia.org/wiki/Tranexamic_acid, lead section
    reditary angioedema. It is taken either by mouth, injection into a vein, or by intramuscular injection.
  • Regulatory approval status
View the Source
2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code B
Quote, First-level anatomical group codes, Code B
Blood and blood forming organs
View the Source
3. Wikipedia
Wikipedia contributors, Wikimedia Foundation
4. WHO Model List of Essential Medicines (Wikipedia)
WikipediaWHO Model List of Essential Medicines, Other medicines administered to the mother section
Quote, WHO Model List of Essential Medicines, Other medicines administered to the mother section
Tranexamic acid
View the Source
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