Cancer treatments that work by directing, enhancing or supplying the immune system's own cells, antibodies or signaling pathways against tumor cells, rather than killing cells directly with a drug or a physical agent. This includes cancer immunotherapy broadly and immunotherapy itself, cell-based approaches (adoptive cell transfer, autologous immune enhancement therapy, CAR T-cell therapy and its chimeric antigen receptor T-cell therapy and CART4-34 variants, cytokine-induced killer cell therapy, T cell receptor T cell therapy, tumor-infiltrating lymphocyte therapy), antibody and checkpoint-based approaches (monoclonal antibody therapy, checkpoint inhibitor therapy, immune checkpoint inhibitor), vaccine and biologic approaches (cancer vaccine, Sipuleucel-T, oncolytic virus therapy, tumor-homing bacteria therapy), and combination or cold-triggered immune approaches (cryoimmunotherapy, combinatorial ablation and immunotherapy). A treatment that uses an immune-system component alongside a chemotherapy drug or a radiation dose whose own mechanism is the defining one is grouped under that mechanism instead.