Marburg Vaccine

A Marburg vaccine would protect against Marburg virus disease, though there are currently no vaccines approved by the United States Food and Drug Administration for its prevention. Many candidate vaccines have been developed and tested in animal models, but none has yet been approved, partly because of economic factors in vaccine development and because filoviruses such as Marburg virus killed relatively few people before the 2010s. The most promising candidates are DNA vaccines or vaccines based on Venezuelan equine encephalitis virus replicons, vesicular stomatitis Indiana virus, or filovirus-like particles, all of which have been shown to protect nonhuman primates from Marburg virus-induced disease, and DNA vaccine candidates have entered clinical trials.