Bcr-Abl tyrosine-kinase inhibitors are the first-line therapy for most patients with chronic myelogenous leukemia, a cancer caused in more than 90 percent of cases by a chromosomal abnormality called the Philadelphia chromosome. That abnormality fuses the Abl tyrosine kinase gene with the Bcr gene to create a constitutively active Bcr-Abl tyrosine kinase, and these drugs were developed to selectively inhibit it.
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Source Bcr-Abl tyrosine-kinase inhibitor (Wikipedia)
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1. Wikipedia
Wikipedia contributors, Wikimedia Foundationhttps://en.wikipedia.org/wiki/Bcr-Abl_tyrosine-kinase_inhibitor, lead sectionQuote, https://en.wikipedia.org/wiki/Bcr-Abl_tyrosine-kinase_inhibitor, lead section
Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML).
Bcr-Abl tyrosine-kinase inhibitor (Wikipedia)
Treats: Chronic Myeloid Leukemia, Lead (321197)Quote, Treats: Chronic Myeloid Leukemia, Lead (321197)
Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML).
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