Double Filtration Plasmapheresis

Double filtration plasmapheresis, or DFPP, is a therapeutic apheresis technique that separates a patient plasma from blood cells with a first plasma separator, then passes the separated plasma through a second, smaller-pore filter that fractionates it into large and small molecular weight components. The large molecular weight fraction, which carries most pathogenic substances such as antibodies, is discarded, while the small molecular weight fraction, including albumin, is returned to the patient, reducing the need for donor plasma replacement compared with conventional plasma exchange. It is used to treat refractory autoimmune, neurological, metabolic and kidney diseases driven by circulating antibodies or other large plasma proteins.