A chloride channel blocker is a type of drug that inhibits the passage of chloride ions through chloride channels in cell membranes. The best known examples named in the source are used in laboratory research rather than as everyday medicines. Niflumic acid is a chloride channel blocker used in experimental work, and anthracene-9-carboxylic acid is a potent blocker of the CLCN1 type of chloride channel found in skeletal muscle, which researchers use to model the inherited muscle disorder myotonia congenita in animals. Some antagonists of glycine receptors and GABA-A receptors also act as chloride channel blockers, so the group overlaps with drugs defined mainly by their receptor targets.
Sources
Chloride channel blocker (Wikipedia)
Reader Challenges (0)
No disputes yet. Spotted an error or a better source? Open the first one.
Sign in to dispute this or suggest a correction.