A release modulator, also called a neurotransmitter release modulator, is a type of drug that changes how much of one or more neurotransmitters a nerve cell releases. The group covers drugs that increase release as well as drugs that reduce it. Monoamine releasing agents, such as the substituted amphetamines, induce the release of norepinephrine, dopamine or serotonin. Release inhibitors work the other way, and botulinum toxin A is the example given: it inactivates SNAP-25, a protein needed for exocytosis, and so stops acetylcholine from being released. Related groups named by the source include reuptake modulators, channel modulators and receptor modulators.
Sources
Release modulator (Wikipedia)
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