Cyclooxygenase-2 inhibitors, commonly called COX-2 inhibitors, are a type of nonsteroidal anti-inflammatory drug that directly target the cyclooxygenase-2 enzyme responsible for inflammation and pain. Their selectivity for COX-2 over the related COX-1 enzyme reduces the risk of peptic ulceration, and this selectivity is the defining feature of drugs in the class such as celecoxib and rofecoxib.
Facts
Origin YearSourced to the subject's own account Sources
1. Wikipedia
Wikipedia contributors, Wikimedia Foundationhttps://en.wikipedia.org/wiki/Cyclooxygenase-2_inhibitor, lead sectionQuote, https://en.wikipedia.org/wiki/Cyclooxygenase-2_inhibitor, lead section
Cyclooxygenase-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly target cyclooxygenase-2 (COX-2), an enzyme responsible for inflammation and pain.
2. Cyclooxygenase-2 Inhibitor (Wikipedia)
WikipediaEarly COX-2-inhibiting drugs sectionQuote, Early COX-2-inhibiting drugs section
Celebrex (and other brand names for celecoxib) was introduced in 1999 and rapidly became the most frequently prescribed new drug in the United States.
Frequently Asked Questions
Why were COX-2 inhibitors developed instead of using older NSAIDs
Their selectivity for the COX-2 enzyme over COX-1 lowers the risk of peptic ulceration compared with older, non-selective NSAIDs.
Cyclooxygenase-2 inhibitors, commonly called COX-2 inhibitors, are a type of nonsteroidal anti-inflammatory drug that directly target the cyclooxygenase-2 enzyme responsible for inflammation and pain. Their selectivity for COX-2 over the related COX-1 enzyme reduces the risk of peptic ulceration, and this selectivity is the defining feature of drugs in the class such as celecoxib and rofecoxib.
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