Intracerebroventricular injection, often abbreviated ICV injection, is a route of drug administration by injection into the brain's cerebral ventricles so that the drug reaches the cerebrospinal fluid, used to bypass the blood brain barrier that can otherwise prevent medications from reaching the central nervous system. In humans it is used for treating spinal muscular atrophy, administering chemotherapy in gliomas, and delivering drugs for long term pain management, and it is also widely used in diseased mouse models to study the effect of drugs, plasmid DNA, and viral vectors on the central nervous system.
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Wikipedia contributors, Wikimedia Foundationhttps://en.wikipedia.org/wiki/Intracerebroventricular_injection, lead sectionQuote, https://en.wikipedia.org/wiki/Intracerebroventricular_injection, lead section
Intracerebroventricular injection is a route of administration for drugs via injection into the cerebral ventricles so that it reaches the cerebrospinal fluid (CSF).
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